Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

126

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

July 1, 2025

Study Completion Date

July 1, 2025

Conditions
Open Angle GlaucomaOcular HypertensionPostoperative Inflammation
Interventions
DRUG

Ketorolac 0.5% Eye Drops

Participants in this arm will receive ketorolac 0.5% eye drops, administered twice daily for one week following Selective Laser Trabeculoplasty (SLT). Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, which play a key role in the inflammatory process. This intervention aims to reduce postoperative inflammation and pain, promoting patient comfort and potentially improving outcomes following SLT.

DRUG

Ketorolac 0.5% and Fluorometholone 0.1% Eye Drops

Participants in this arm will receive a combination of ketorolac 0.5% eye drops and fluorometholone 0.1% eye drops. Ketorolac will be administered twice daily and fluorometholone four times daily for one week following SLT. Fluorometholone is a corticosteroid that reduces inflammation by stabilizing capillary permeability and inhibiting inflammatory cell activation. The combination aims to maximize anti-inflammatory effects and enhance patient comfort, potentially leading to better postoperative outcomes compared to ketorolac alone or no treatment.

Trial Locations (1)

L8G 4X3

St. Joseph's Healthcare Hamilton, Hamilton Regional Eye Institute, Hamilton

All Listed Sponsors
lead

St. Joseph's Healthcare Hamilton

OTHER

NCT06498440 - Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT | Biotech Hunter | Biotech Hunter