124
Participants
Start Date
June 28, 2024
Primary Completion Date
June 30, 2026
Study Completion Date
June 30, 2027
Prednisone
This drug will be used in both arms. Patients' initial daily prednisone dose will be calculated according to their weights (0.6mg \* weight(kg), maximum 50mg/day), and then tapered gradually during the study course.
Methotrexate
This drug will be used in the traditional arm. A dose of 15mg per week will be used.
Tocilizumab
This drug will be used in the precise treatment arm. For patients in constitutional type a dose (8mg/kg weight) will be used every 2 weeks (iv drip) for 12 weeks, then a dose (8mg/kg weight) will be used every 4 weeks (iv drip). For patients in vascular inflammation type, a dose (8mg/kg weight) will be used every 4 weeks (iv drip).
Tofacitinib
This drug will be used in the precise treatment arm. A sustained release tablet will be used (11mg per day).
Adalimumab
This drug will be used in the precise treatment arm. A dose of 40mg (ih) will used every 2 weeks.
RECRUITING
Zhongshan Hospital, Fudan University, Shanghai
Shanghai Zhongshan Hospital
OTHER