Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

PHASE2RecruitingINTERVENTIONAL

Enrollment

295

Participants

Timeline

Start Date

February 13, 2025

Primary Completion Date

May 1, 2029

Study Completion Date

March 1, 2031

Conditions

LymphedemaFibrosis

Interventions

DRUG

Pravastatin

Given by PO

DRUG

Pentoxifylline

Given by PO

DRUG

Tocopherol

Given by PO

Trial Locations (1)

RECRUITING

MD Anderson Cancer Center, Houston

All Listed Sponsors

lead

M.D. Anderson Cancer Center

OTHER