A Phase 2 Open-label Single-arm Trial of JAK1 Inhibitor for the Treatment of Large Inflammatory Hepatocellular Adenomas

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

September 2, 2024

Primary Completion Date

September 2, 2028

Study Completion Date

September 2, 2028

Conditions
Inflammatory Hepatocellular Adenoma
Interventions
DRUG

Baricitinib

An ancillary study will be performed in a subgroup of 12 patients to assess the variation of the results of PET-CT with 18FDG from baseline to 3 months. The variation of tumor features assessed by PET-CT with 18FDG after three months of treatment, will be assessed. The median value of the SUV max and tumor to non-tumor ratio of the SUV max value for each HCA lesion between the PET CT with 18FDG performed at baseline and after 3 months of treatment will be assessed.

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER