Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

April 22, 2024

Primary Completion Date

April 22, 2025

Study Completion Date

April 22, 2026

Conditions
Fetal HemoglobinThalassemia MajorGenetic Disease
Interventions
DRUG

Thalidomide

"Thalidomide is being investigated for its therapeutic efficacy and safety profile in transfusion-dependent beta thalassemia patients.~Participants in this arm received thalidomide. Thalidomide was administered orally at a dosage of 5-6mg/kg/day. The medication was taken continuously or on a specified schedule (e.g., daily,) for the duration of the study period, which lasted 2 years. Participants were monitored for adherence to the medication regimen and for any adverse effects throughout the intervention period."

DRUG

Thalidomide

"Thalidomide is being investigated for its therapeutic efficacy and safety profile in transfusion-dependent beta thalassemia patients.~Participants in this arm received thalidomide. Thalidomide was administered orally at a dosage of 7-8mg/kg/day. The medication was taken continuously or on a specified schedule (e.g., daily,) for the duration of the study period, which lasted 2 years. Participants were monitored for adherence to the medication regimen and for any adverse effects throughout the intervention period."

Trial Locations (1)

Unknown

RECRUITING

National Institute of blood disease and bone marrow transplant, Karachi

All Listed Sponsors
lead

National Institute of Blood and Marrow Transplant (NIBMT), Pakistan

OTHER_GOV

NCT06490627 - Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia | Biotech Hunter | Biotech Hunter