Inhaled Colistin to Prevent Pediatric Ventilator-associated Pneumonia

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

April 1, 2027

Study Completion Date

April 1, 2027

Conditions
Ventilator Associated Pneumonia
Interventions
DRUG

colistimethate sodium

100 000 IU/kg of colistimethate sodium (equivalent to 0.96 mg/kg of colistin base) ,maximum 750000 IU, will be nebulized daily, divided into two doses for a maximum of 7 days for eligible ventilated children starting from day 3 of mechanical ventilation.

DRUG

0.9% Saline

Nebulization of 3 ml of 0.9% saline twice a day for a maximum of 7 days from day 3 of invasive mechanical ventilation for eligibile ventilated children

All Listed Sponsors
lead

University Hospital Fattouma Bourguiba

OTHER

NCT06488794 - Inhaled Colistin to Prevent Pediatric Ventilator-associated Pneumonia | Biotech Hunter | Biotech Hunter