Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and Ependymoma

"1. st stage:~ * Axitinib (Inlyta®) PO, in the morning and in the evening every day~ * Level -1 : Dose 1.2 mg/m²~ * Level 1: Dose 1.6 mg/m²~ * Level 2: Dose 2.0 mg/m²~ * Level 3: Dose 2.4 mg /m² (equivalent to 4 mg in adults)~ * Etoposide (50 mg capsules or in the form of etoposide phosphate if required): 25 mg/m²/day in the evening orally every day fasting (capped to a maximum of 50 mg/day) First patient will be enrolled at dose level 1~2. nd stage:~ * Axitinib (Inlyta®) dosing as selected at the 1st stage~ * Etoposide (50 mg capsules or in the form of etoposide phosphate if required): 25 mg/m2/ day in the evening orally every day fasting(capped to a maximum of 50 mg/day)"