Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide

NAActive, not recruitingINTERVENTIONAL
Enrollment

315

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2027

Conditions
ObesityWeight Change TrajectoryWeight Change, Body
Interventions
DEVICE

Revita Duodenal Mucosal Resurfacing (DMR)

DMR is designed to ablate and re-epithelialize the duodenal mucosal surface, thus allowing nutrients to be exposed to a newly regrown and potentially normalized local mucosa. This implies that the duodenal mucosa surface is abnormal in participants associated with metabolic disorders. The Revita DMR procedure is performed endoscopically with supporting fluoroscopy.

DEVICE

Sham

An endoscopic review with non active catheter introduction

Trial Locations (32)

10016

NYU-Langone, New York

11106

NYC Research, Inc. (Endocrine Associates of West Village), Long Island City

15243

Preferred Primary Care Physician Pittsburgh, Pittsburgh

15326

Preferred Primary Care Physician, Pittsburgh

15401

Preferred Primary Care Physician, Uniontown

26506

West Virginia University, Morgantown

32162

Nature Coast Clinical Research, Inverness

Synexus Clinical Research Institute - The Villages (AES), The Villages

32216

Jacksonville Center for Clinical Research, Jacksonville

32256

Encore Borland-Groover Clinical Research, Jacksonville

32804

Advent Health, Orlando

32806

K2 Medical Research South Orlando, Orlando

Orlando Health Weight Loss and Bariatric Surgery Institute, Orlando

33021

Zenith Clinical Research, Hollywood

33183

International Research Associates, Miami

33331

Cleveland Clinic, Weston, Weston

33401

Metabolic Research Institute, West Palm Beach

46112

Investigators Research Group, LLC, Brownsburg

46131

American Health Network - Franklin, Franklin

46140

American Health Network - Greenfield, Greenfield

46202

Indiana University, Indianapolis

47304

American Health Network - Muncie, Muncie

48109

University of Michigan, Ann Arbor

77030

Baylor St. Luke's Medical Center, Houston

77040

Juno Research, LLC, Houston

77478

Simcare Medical Research LLC, Sugar Land

85028

Helios Clinical Research, Phoenix

85258

Honor Health, Scottsdale

90095

UCLA Santa Monica Medical Center, Santa Monica

92663

Hoag Hospital, Newport Beach

98109

University of Washington, Seattle, Seattle

03756

Dartmouth-Hitchcock Medical Center, Lebanon

Sponsors
All Listed Sponsors
lead

Fractyl Health Inc.

INDUSTRY