Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

February 6, 2025

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2027

Conditions
Pancreatic AdenocarcinomaMetastatic Pancreatic CancerBasal Cell Neoplasm
Interventions
DRUG

Gemcitabine

1000 mg/m2, intravenously on day 1 and day 15, for subjects with basal-like cell type pancreatic carcinoma.

DRUG

Nab paclitaxel

125 mg/m2 intravenously on day 1 and day 15 for subjects with basal-like cell type pancreatic carcinoma.

DRUG

Erlotinib

50 mg per oral daily. for subjects with basal-like cell type pancreatic carcinoma.

DRUG

NALIRIFOX

Subjects with classical pancreatic adenocarcinoma will receive. NALIRIFOX is liposomal irinotecan with 5-fluorouracil/leucovorin and oxaliplatin. Dosing and plan will be decided by the treating physician.

DRUG

Folfirinox

Subjects with classical pancreatic adenocarcinoma will receive. Dosing and plan will be decided by the treating physician.

Trial Locations (1)

27599

RECRUITING

University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center, Chapel Hill

All Listed Sponsors
lead

UNC Lineberger Comprehensive Cancer Center

OTHER