Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery

NARecruitingINTERVENTIONAL
Enrollment

568

Participants

Timeline

Start Date

July 28, 2025

Primary Completion Date

August 31, 2028

Study Completion Date

February 28, 2029

Conditions
Older PatientsCognitive ImpairmentRepetitive Transcranial Magnetic StimulationDelayed Neurocognitive RecoveryPostoperative Neurocognitive Disorder
Interventions
DEVICE

Repetitive transcranial magnetic stimulation

"Repeated transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for a 5-day period (1 day before surgery and 4 consecutive days after surgery, twice daily \[10-12 am and 6-8 pm\], no intervention on the day of the surgery). Parameters of rTMS: 8 shaped coil, 10 Hz, 80% resting motor threshold (RMT), 2000 pulses (5s × 40 trains, 25 s interval), 20 minutes."

DEVICE

Sham stimulation

"Sham repeated transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for a 5-day period (1 day before surgery and 4 consecutive days after surgery, twice daily \[10-12 am and 6-8 pm\], no intervention on the day of the surgery). Parameters of rTMS: 8 shaped sham coil, 10 Hz, 80% resting motor threshold (RMT), 2000 pulses (5s × 40 trains, 25 s interval), 20 minutes."

Trial Locations (3)

100034

RECRUITING

Peking University First Hospital, Beijing

516473

NOT_YET_RECRUITING

Peking University Shenzhen Hospital, Shenzhen

710032

NOT_YET_RECRUITING

Xijing Hospital, Air Force Medical University, Xi'an

All Listed Sponsors
collaborator

The First Affiliated Hospital of Air Force Medicial University

OTHER

collaborator

Peking University Shenzhen Hospital

OTHER

lead

Peking University First Hospital

OTHER

NCT06482749 - Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery | Biotech Hunter | Biotech Hunter