Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

June 1, 2021

Primary Completion Date

December 1, 2024

Study Completion Date

December 1, 2025

Conditions
Locally Advanced Thyroid Gland Carcinoma
Interventions
DRUG

Anlotinib

8/10/12 mg qd, po. Stop the medication for one week after taking it for two weeks.

DRUG

Lenvatinib

8/12 mg qd, po.

DRUG

Sorafenib

0.4 g bid, po.

DRUG

Donafenib

0.3 g bid, po.

DRUG

Everolimus

10 mg qd, po.

DRUG

Apatinib

500 mg qd, po.

DRUG

Dabrafenib + Trametinib

Dabrafenib 150 mg bid, po+Trametinib 2 mg qd, po.

DRUG

Cabozantinib

Cabozantinib 60mg qd, po.

DRUG

Vandetanib

Vandetanib 300mg qd, po.

DRUG

Entrectinib

Entrectinib 600mg qd,po.

DRUG

Pralsetinib

400mg qd, po.

DRUG

Larotrectinib

100mg qd,po

Trial Locations (1)

610041

RECRUITING

West China hospital, Chengdu

All Listed Sponsors
lead

West China Hospital

OTHER