Prognostic Value of Measuring CtDNA in a Cohort of Patients With Stage III and IV Upper Aero-digestive Tract (UADT) Cancer , Treated With Curative RADiOtherapy With or Without Concomitant Treatment.

NARecruitingINTERVENTIONAL
Enrollment

188

Participants

Timeline

Start Date

September 30, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2029

Conditions
SCC - Squamous Cell CarcinomaUpper Aero-digestive Tract (UADT) Neoplasm
Interventions
OTHER

Blood samples

"A blood sample of 20 mL (2 tubes of 10 mL) for research purposes will be collected during:~* The day of the centering scan (Visit 1);~* During treatment at Week 2 and Week 6 (+/- 1 week) (Visit 2 and 3);~* The day of the post-therapeutic visit scheduled between 3 and 5 weeks after the end of radiotherapy, whether or not associated with concomitant treatment (Visit 4);~* At each monitoring visit following radiotherapy associated or not with concomitant treatment (every 3 months for 24 months (V5 to V12 ; V12 = final visit)~* When the disease progresses before initiation of the 2nd line of treatment."

Trial Locations (7)

8091

RECRUITING

University Hospital Zurich (USZ), Zurich

14076

NOT_YET_RECRUITING

Centre François Baclesse, Caen

21000

NOT_YET_RECRUITING

Centre Georges-François Leclerc, Dijon

25030

NOT_YET_RECRUITING

CHU Besançon, Besançon

51100

RECRUITING

Intitut Jean Godinot, Reims

54500

RECRUITING

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

67033

RECRUITING

Institut de Cancérologie Strasbourg Europe, Strasbourg

All Listed Sponsors
lead

Institut de Cancérologie de Lorraine

OTHER