Prospective Clinical Study of Orelabrutinib in Combination With Rituximab (OR) for Primary Marginal Zone Lymphoma (MZL) That Failed or Not Suitable for Local Therapy

NARecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

June 23, 2024

Primary Completion Date

June 23, 2027

Study Completion Date

June 23, 2027

Conditions
Marginal Zone Lymphoma
Interventions
DRUG

Orelabrutinib in combination with rituximab

"Induction Phase:~Orelabrutinib + rituximab for a total of 6 cycles of 28 days each Obrutinib (O) 150mg oral d1-28 Rituximab (R) 375mg/m2 IV d0~Maintenance phase:~Orelabrutinib 150mg po qd 24 cycles of 28 days each"

Trial Locations (1)

361003

RECRUITING

Bing, Xu, Xiamen

All Listed Sponsors
collaborator

The First Hospital of Jilin University

OTHER

collaborator

Fujian Cancer Hospital

OTHER_GOV

collaborator

Guangdong Provincial People's Hospital

OTHER

collaborator

Nanfang Hospital, Southern Medical University

OTHER

collaborator

The Second Affiliated Hospital of Dalian Medical University

OTHER

collaborator

Jiangxi Provincial Cancer Hospital

OTHER

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Shaanxi Provincial Cancer Hospital

OTHER

collaborator

Chinese PLA General Hospital

OTHER

lead

The First Affiliated Hospital of Xiamen University

OTHER