Validation of Hematological Indices

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

June 19, 2023

Primary Completion Date

November 1, 2025

Study Completion Date

December 30, 2025

Conditions
Multiple Organ DysfunctionSepsisPneumoniaWound Infection
Interventions
DIAGNOSTIC_TEST

Determination of the level of the studied biomarkers

Determination of the level of hematological indices based on a general blood test; Determination of the levels of the following biomarkers: isolation of neutrophils from the blood using the gradient centrifugation method; assessment using enzyme immunoassay (ELISA) of the content of neutrophil elastase in the supernatant; myeloperoxidase, ELISA; lactoferrin, ELISA; interleukin -1ß,17,10,6, ELISA; presepsin, ELISA; endothelin, ELISA; lipopolysaccharide, LAL test; lipopolysaccharide binding protein, ELISA; NETs release, immunofluorescence method; the number of neutrophils expressing PDL-1, flow cytofluorimetry method; procalcitonin in human plasma and serum, VIDAS B.R.A.H.M.S. PCT; ferritin, reagent for determination (FERRITIN); lactate dehydrogenase, reagent for determination of QSR6128;Endotoxin Activity Assay, chemiluminescent immunodiagnostics.

Trial Locations (1)

119991

RECRUITING

Petrovsky National Reasearch Centre of Surgery, Moscow

All Listed Sponsors
lead

Petrovsky National Research Centre of Surgery

OTHER