Neoadjuvant/Adjuvant Tislelizumab Combined With Anlotinib and Platinum Doublet Chemotherapy With Resectable NSCLC

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

June 30, 2024

Primary Completion Date

June 10, 2025

Study Completion Date

December 31, 2027

Conditions
Non-Small Cell Lung CancerAnti Angiogenesis
Interventions
DRUG

Immunochemotherapy combined with antiangiogenic

neoadjuvant: Tislelizumab 200mg iv,d1,q3w, Anlotinib 10mg,po,qd1-14,q3w, Cisplatin 75 mg/m\^2 by IV infusion Q3W, given on cycle day 1 Carboplatin AUC of 5 on Day 1 of each 3-week cycle Paclitaxel 175mg/m2 on Day 1 of each 3-week cycle(SQ only) Albumin-bound paclitaxel 260mg/m2,on D1 IV infusion Q3W or 130mg/m2 on D1D8 IV infusion Q3W for each cycle(SQ only) Pemetrexed 500 mg/m2 on Day 1 of each 3-week cycle(NSQ only) Adjuvant: 4 weeks(±7 Days) following surgery, participants receive no more than 16 cycles (cycle length: 3 weeks) of Tislelizumab \[200 mg, IV; given on cycle day 1\].

DRUG

Immunochemotherapy

neoadjuvant:Tislelizumab 200mg iv,d1,q3w, Cisplatin 75 mg/m\^2 by IV infusion Q3W, given on cycle day 1 Carboplatin AUC of 5 on Day 1 of each 3-week cycle Paclitaxel 175mg/m2 on Day 1 of each 3-week cycle(SQ only) Albumin-bound paclitaxel 260mg/m2,on D1 IV infusion Q3W or 130mg/m2 on D1D8 IV infusion Q3W for each cycle(SQ only) Pemetrexed 500 mg/m2 on Day 1 of each 3-week cycle(NSQ only) Adjuvant: 4 weeks(±7 Days) following surgery, participants receive no more than 16 cycles (cycle length: 3 weeks) of Tislelizumab \[200 mg, IV; given on cycle day 1\].

Trial Locations (1)

710000

Tangdu Hospital of the Fourth Millitary Medical University, Xi'an

All Listed Sponsors
lead

Tang-Du Hospital

OTHER

NCT06475755 - Neoadjuvant/Adjuvant Tislelizumab Combined With Anlotinib and Platinum Doublet Chemotherapy With Resectable NSCLC | Biotech Hunter | Biotech Hunter