38
Participants
Start Date
July 9, 2024
Primary Completion Date
January 3, 2025
Study Completion Date
June 6, 2025
TE-8105 SAD Cohort 1
Each participant will receive one dose of TE-8105 0.5 up to 1.5mg injection via subcutaneous (SC) injection into the abdomen administered on Day 1.
TE-8105 SAD Cohort 3
Each participant will receive one dose of TE-8105 1.5 mg or less than or equal to 2.5 mg injection via subcutaneous (SC) injection into the abdomen administered on Day 1.
TE-8105 SAD Cohort 5 (Adaptive cohort)
Each participant will receive one dose of TE-8105 less than or equal to 6 mg injection via subcutaneous (SC) injection into the abdomen administered on Day 1.
TE-8105 MAD Cohort 1
Each participant will receive 0.5mg up to 1.5mg of TE-8105 injection via SC injection into the abdomen on Day 1 and then once every 2 weeks for 5 doses.
TE-8105 MAD Cohort 2
Each participant will receive 9 doses of TE-8105 injection via SC injection into the abdomen starting from Day 1 every 2 weeks. Dose will be titrated up by 0.5mg every 4 weeks, with dose levels of 1.5mg (2 doses), 2.0 mg (2 doses), 2.5 mg (2 doses) and 3.0 mg (3 doses)
TE-8105 SAD Cohort 2
Each participant will receive one dose of TE-8105 0.75mg injection via subcutaneous (SC) injection into the abdomen on Day 1.
TE-8105 SAD Cohort 4
Each participant will receive one dose of TE-8105 3 mg or less than or equal to 5 mg injection via subcutaneous (SC) injection into the abdomen administered on Day 1.
CMAX Clinical Research, Adelaide
Lead Sponsor
Immunwork, Inc.
INDUSTRY