Clinical Trial to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Adults With CF

PHASE2RecruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

June 3, 2024

Primary Completion Date

April 1, 2025

Study Completion Date

June 1, 2025

Conditions
Cystic Fibrosis
Interventions
DRUG

Diponecaftor

"Diponecaftor is a triple combination of DIR/POS/NES. The combination therapy will be administered orally during 8 weeks. The daily dose contains:~* DIR 300 mg/day~* POS 600 mg/day~* NES 10 mg/day"

DRUG

Placebo

Placebo once daily for 8 weeks. Oral administration.

Trial Locations (16)

Unknown

NOT_YET_RECRUITING

UZ Leuven, Leuven

NOT_YET_RECRUITING

CHU de Nice, Nice

NOT_YET_RECRUITING

Hôpital Larrey CHU Toulouse, Toulouse

NOT_YET_RECRUITING

Charité Universitätsmedizin Berlin, Berlin

NOT_YET_RECRUITING

Medizinische Hochschule Hannover, Hanover

NOT_YET_RECRUITING

Instituto Giannina Gaslini, Genova

NOT_YET_RECRUITING

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan

NOT_YET_RECRUITING

Ospedale Pediatrico Bambino Gesù, Rome

NOT_YET_RECRUITING

Azienda Ospedaliera Universitaria Integrata, Verona

NOT_YET_RECRUITING

Hospital de Santa Maria, Lisbon

NOT_YET_RECRUITING

Hospital Vall d'Hebron, Barcelona

RECRUITING

Sahlgrenska University Hospital, Gothenburg CF center, Gothenburg

NOT_YET_RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

NOT_YET_RECRUITING

Royal Brompton Hospital, London

NOT_YET_RECRUITING

University Hospital Southampton, Southampton

3584 CX

RECRUITING

UMC Utrecht, Utrecht

All Listed Sponsors
collaborator

European Union

OTHER

lead

Kors van der Ent

OTHER