Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

2,900

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

April 30, 2029

Conditions
Gonorrhea MaleChlamydia (Male)Syphilis Male
Interventions
DRUG

WHO-recommended periodic presumptive treatment

400 mg po cefixime plus 1 gram azithromycin po under direct observation

DRUG

Doxycycline post-exposure prophylaxis

200 mg po doxycycline within 24-72 hours after condomless anal or vaginal sex as frequently as daily

All Listed Sponsors
collaborator

Aurum Institute

OTHER

collaborator

Nyanza Reproductive Health Society

OTHER

collaborator

Partners for Health and Development in Africa

UNKNOWN

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

lead

University of Washington

OTHER