36
Participants
Start Date
October 27, 2025
Primary Completion Date
September 28, 2029
Study Completion Date
April 1, 2030
Functional Substrate-Only Mapping without VT Induction
In this arm, invasive maps will be constructed by annotating the latest deflection and peak frequency during voltage mapping of stable intrinsic rhythm to localize areas of slow conduction. Annotated algorithms are cleared by the FDA. No VT will be purposefully induced in this experimental arm.
Standard-of-Care Mapping/Imaging
Conventional invasive scar (voltage) and electrical VT (entrainment, activation, pace) mapping will be used to guide VT ablation. Functional substrate mapping will not be used in this arm. VT will be induced using standard protocols.
VA San Diego Healthcare System, San Diego, CA, San Diego
VA Office of Research and Development
FED