Functional Substrate-Only Guided VT Ablation

NANot yet recruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

October 27, 2025

Primary Completion Date

September 28, 2029

Study Completion Date

April 1, 2030

Conditions
Ventricular TachycardiaSudden Cardiac Death
Interventions
PROCEDURE

Functional Substrate-Only Mapping without VT Induction

In this arm, invasive maps will be constructed by annotating the latest deflection and peak frequency during voltage mapping of stable intrinsic rhythm to localize areas of slow conduction. Annotated algorithms are cleared by the FDA. No VT will be purposefully induced in this experimental arm.

PROCEDURE

Standard-of-Care Mapping/Imaging

Conventional invasive scar (voltage) and electrical VT (entrainment, activation, pace) mapping will be used to guide VT ablation. Functional substrate mapping will not be used in this arm. VT will be induced using standard protocols.

Trial Locations (1)

92161-0002

VA San Diego Healthcare System, San Diego, CA, San Diego

All Listed Sponsors
lead

VA Office of Research and Development

FED

NCT06464315 - Functional Substrate-Only Guided VT Ablation | Biotech Hunter | Biotech Hunter