ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

69

Participants

Timeline

Start Date

January 31, 2025

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
Acute Myeloid LeukemiaMyelodysplastic Syndromes
Interventions
DRUG

TCB008

TCB008 is derived from the peripheral blood mononuclear cells (PBMCs) of unrelated, healthy donors and consists of expanded cluster designation (CD)3+ T cells expressing the γ chain variable region 9 δ-chain variable region 2 (Vγ9Vδ2) T cell receptor (TCR); it is infused into patients to boost their immune system. It is currently developed for treatment of cancers and infectious diseases.

Sponsors

Lead Sponsor

All Listed Sponsors
lead

TC Biopharm

INDUSTRY

NCT06463327 - ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML | Biotech Hunter | Biotech Hunter