Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer

NANot yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

July 5, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Irinotecan Hydrochloride Liposome Injection;Carboplatin Injection;Serplulimab Injection

"Cohort 1: Liposomal irinotecan: 50mg/m2, ivgtt, d1; Carboplatin AUC=5, ivgtt, d1; Serplulimab: 4.5mg/kg, ivgtt, d1; The drug was administered once every three weeks for a total of 4 cycles. After 4 cycles, serplulimab is maintained until disease progression or toxicity becomes intolerable.~Cohort 2: Etoposide: 100 mg/m2, ivgtt, d1-3; Carboplatin AUC=5, ivgtt, d1; Serplulimab: 4.5mg/kg, ivgtt, d1; The drug was administered once every three weeks for a total of 4 cycles. After 4 cycles, serplulimab is maintained until disease progression or toxicity becomes intolerable."

All Listed Sponsors
collaborator

Sun Yat-sen University

OTHER

collaborator

Hunan Cancer Hospital

OTHER

collaborator

Guangdong Provincial Hospital of Traditional Chinese Medicine

OTHER

collaborator

First People's Hospital of Foshan

OTHER

collaborator

Youjiang Medical College for Nationalities

OTHER

lead

Zhou Chengzhi

OTHER

NCT06462105 - Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter