A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

PHASE4RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Nasopharyngeal Cancer Recurrent
Interventions
DRUG

Toripalimab

Participants will receive toripalimab via intravenous infusion (IV) on Day 1 every 3 weeks (Q3W) during the Chemotherapy-based treatment phase and Maintenance treatment phase.

DRUG

Cisplatin

Participants will receive cisplatin via IV on Day 1 Q3W during the Chemotherapy-based treatment phase.

DRUG

Gemcitabine

Participants will receive gemcitabine via IV on Day 1 and Day 8 Q3W during the Chemotherapy-based treatment phase.

DRUG

Carboplatin

In the event of cisplatin-related nephrotoxicity or at the discretion of the investigator due to cisplatin-related poor tolerability, carboplatin can substitute for cisplatin use from cycle 2 onward. These participants will receive carboplatin via IV on Day 1 Q3W during the Chemotherapy-based treatment phase.

Trial Locations (11)

10016

RECRUITING

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

30322

RECRUITING

Emory Winship Cancer Institute, Atlanta

44195

RECRUITING

Cleveland Clinic, Cleveland

45219

RECRUITING

University of Cincinnati Medical Center, Cincinnati

48109

RECRUITING

University of Michigan, Ann Arbor

53226

RECRUITING

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

92697

RECRUITING

University of California, Irvine, Irvine

94115

RECRUITING

University of California, San Francisco, San Francisco

02118

RECRUITING

Boston Medical Center, Boston

MSG 1Z5

RECRUITING

Princess Margaret Cancer Centre, Toronto

Sponsors
All Listed Sponsors
lead

Coherus Oncology, Inc.

INDUSTRY