A Phase II Clinical Trial of Flonoltinib Maleate Tablet in Intermediate-High Risk Myelofibrosis

PHASE2RecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

May 6, 2024

Primary Completion Date

May 6, 2026

Study Completion Date

July 6, 2026

Conditions
MF,PMF,PPV-MF,PET-MF
Interventions
DRUG

Flonoltinib 50mg

Flonoltinib 50mg, QD

DRUG

Flonoltinib 100mg

Flonoltinib 100mg, QD

DRUG

Ruxolitinib

For patients with platelet counts between 100×10\^9/L and 200×10\^9/L, the recommended starting dose is 15 mg twice daily (bid). For patients with platelet counts \>200×10\^9/L, the recommended starting dose is 20 mg bid. For patients with platelet counts between 50×10\^9/L and \<100×10\^9/L, the recommended maximum starting dose is 5 mg bid.

Trial Locations (2)

300052

RECRUITING

Hematology Hospital, Chinese Academy of Medical Sciences, Tianjin

610000

RECRUITING

West China Hospital Sichuan University, Chengdu

All Listed Sponsors
lead

Chengdu Zenitar Biomedical Technology Co., Ltd

INDUSTRY