Adaptions and Resiliency to Multi-Stressor OpeRations

Goserelin acetate (Zoladex) is a gonadotropin-releasing hormone agonist (GnRH). GnRH agonists induce a transient increase in sex hormone concentrations, but subsequently inhibit gonadotropin secretion and the production of testosterone in men and estrogen in women. An equilibration period will occur to allow steroid concentrations to reduce.

A 4-week physical training program that mimics military training.

Male subjects will be randomly assigned to receive a topical testosterone gel (5g dose).

Male subjects will be randomly assigned to receive a topical testosterone gel (1.25g dose).

Female subjects will be randomly assigned to receive a estrogen/ progesterone patch.

Female subjects will be randomly assigned to receive a placebo patch identical to the Climara Pro patch.