Daratumumab/Daratumumab and Hyaluronidase-fihj in Combination With Pomalidomide and Dexamethasone for the Treatment of Patients With Newly Diagnosed AL Amyloidosis: a Prospective, Multicenter, Single-arm Study

NARecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

January 1, 2025

Study Completion Date

March 1, 2025

Conditions
Amyloid Light-chain Amyloidosis
Interventions
DRUG

Daratumumab/daratumumab and hyaluronidase-fihj

Daratumumab/daratumumab and hyaluronidase-fihj: Dara SC 1800mg subcutaneous (IH) or Dara 16mg/kg intravenously (IV) administered weekly (qwk) x 4 every 2 weeks X 3 doses per month starting C7.

DRUG

Pomalidomide

Pomalidomide: pom 2-4mg PO day (D) 1-21/28 (adjust dose for renal function).

DRUG

Dexamethasone

Dexamethasone: dex C1: 20mg IV D1/8, 20mg PO D2/9 and 40mg PO C1D15 weekly up to C6, then 20mg IV monthly starting C7D1 and 20mg PO D8, 15, 22.

Trial Locations (1)

325000

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

All Listed Sponsors
lead

Yongyong MA

OTHER