A Study of SIPLIZUMAB in AILD and LT Patients

PHASE1RecruitingINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

September 11, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

March 31, 2026

Conditions
Autoimmune Liver DiseaseLiver Transplant DisorderAutoimmune HepatitisPrimary Sclerosing CholangitisEnd Stage Liver DIseaseCirrhosis, Liver
Interventions
DRUG

Siplizumab

Siplizumab is an anti-CD2 monoclonal antibody that has demonstrated a favorable safety profile of siplizumab in over 779 human subjects and has been shown to target memory T cells-a key driver in the immune processes surrounding rejection and autoimmunity post LT in AILD.

Trial Locations (1)

10032

RECRUITING

Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York

All Listed Sponsors
collaborator

ITB-Med LLC

INDUSTRY

lead

Elizabeth C. Verna

OTHER