Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC.

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

June 6, 2024

Primary Completion Date

June 1, 2025

Study Completion Date

June 1, 2027

Conditions
Esophageal Cancer
Interventions
DRUG

Induction immunochemotherapy followed by Adebrelimab plus concurrent chemoradiotherapy

"Induction immunochemotherapy:~Nab-paclitaxel:220mg/m2,IV,d1,d22; Carboplatin:AUC=5,IV,d1,d22; Adebrelimab:1200mg, IV,d1, d22.~Evaluation of the Curative Effect:CR+PR~Adebrelimab plus concurrent chemoradiotherapy:~Adebrelimab:1200mg, IV,q3w, until PD; Nab-paclitaxel:175mg/m2,IV,d1,d22; Carboplatin:AUC=5,IV,d1,d22; Radiotherapy:50.4Gy/1.8Gy/28f."

DRUG

Induction immunochemotherapy followed by concurrent chemoradiotherapy

"Induction immunochemotherapy:~Nab-paclitaxel:220mg/m2,IV,d1,d22; Carboplatin:AUC=5,IV,d1,d22; Adebrelimab:1200mg, IV,d1, d22.~Evaluation of the Curative Effect:SD+PD~Concurrent chemoradiotherapy:~Oxaliplatin:85 mg/m2,IV,d1,d15,d29; Leucovorin:400mg/m2,IV,d1,d15,d29; 5-FU:400mg/m2,IV,d1,d15,d29; 5-FU:1600mg/m2,CIV48h,d1,d15,d29; Radiotherapy:PTV/PGTV:50.4Gy/59.92Gy/28f."

Trial Locations (1)

300060

Tianjin Cancer Hospital, Tianjin

All Listed Sponsors
lead

Tianjin Medical University Cancer Institute and Hospital

OTHER

NCT06452602 - Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC. | Biotech Hunter | Biotech Hunter