VMAC+DLI Treatment of Patients With Relapse of AML After Allo-HSCT

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 12, 2024

Primary Completion Date

May 31, 2027

Study Completion Date

October 31, 2027

Conditions
Relapse Acute Myeloid Leukemia
Interventions
DRUG

Mitoxantrone hydrochloride liposome

Veneclatra (VEN) 400 mg/d (reduced to 100 mg when combined with an azole), d1-7; Mitoxantrone Liposomal 30 mg/m2, d1; Cytosine arabinoside(Ara-C) 100 mg/m2/d, d1-7; Cyclophosphamide (CTX) 400 mg/m2/d, d2, 5); After 1 day of rest, cryopreserved donor stem cells MNC1-2X10\^8 /kg infusion, add low-dose (25 mg Bid) and short-course treatment (stop 2-3 weeks after DLI) oral cyclosporine (CSA) to prevent graft-versus-host disease (GVHD) 3 days before cryopreserved stem cell infusion.

Trial Locations (1)

300000

RECRUITING

Institute of Hematology & Blood Diseases Hospital, China, Tianjin

All Listed Sponsors
lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER