Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

June 30, 2024

Primary Completion Date

June 30, 2025

Study Completion Date

December 30, 2026

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Tislelizumab

Patients will undergo two cycles of immunotherapy, each cycle lasting 21 days. Day 3 and Day 24: Tislelizumab, fixed dose of 200 mg

RADIATION

Low-dose radiotherapy

Patients will undergo two cycles of low-dose radiotherapy. Day 1/2 and Day 22/23: Low-dose radiotherapy (8 Gy/4f)

DRUG

Nab-paclitaxel

Patients will undergo two cycles of chemotherapy. Day 3 and Day 24: Nab-paclitaxel 260 mg/m2

DRUG

Cisplatin

Patients will undergo two cycles of chemotherapy. Day 3 and Day 24: Cisplatin 75 mg/m2.

Trial Locations (1)

610000

RECRUITING

Sichuan University West China Hospital, Chengdu

All Listed Sponsors
lead

Sichuan University

OTHER