Adjunctive Doxycycline for Central Nervous System Tuberculosis

adjunctive doxycycline to standard anti-tuberculous treatment and corticosteroid therapy

Placebo

Standard anti-tuberculous therapy

Adjunctive corticosteroids to be dosed at 0.4mg/kg/day of dexamethasone or equivalent for week 1, then 0.3mg/kg/day for week 2, 0.2mg/kg/day for week 3, 0.1mg/kg/day for week 4, then tapered to stop over the next 4 weeks. Other forms of corticosteroids are also acceptable eg. hydrocortisone, methylprednisolone at the equivalent dosage