240
Participants
Start Date
August 12, 2024
Primary Completion Date
March 31, 2028
Study Completion Date
March 31, 2029
Buprenorphine Patch
Buprenorphine patch dosing will be individualized based on each participant's current morphine-equivalent dose (per package insert/recommendations; between 5mcg and 20mcg per hour). Dosage based on baseline MEQ (\<30 MEQ = 5mcg/hr patch, 30-80 MEQ =10-15mcg/hour patch; \>80 MEQ = 20mcg/hour patch), which will remain on for 7 days (Phase Ia Days 1-7), as tolerated
Placebo
double-blinded randomization to placebo or transdermal buprenorphine
Transcranial Magnetic Stimulation (TMS)
double-blinded randomization to REAL intermittent theta burst (iTBS) rTMS
Sham Transcranial Magnetic Stimulation (TMS)
double-blinded randomization to SHAM intermittent theta burst (iTBS) rTMS
RECRUITING
Medical University of South Carolina, Charleston
National Institute on Drug Abuse (NIDA)
NIH
Medical University of South Carolina
OTHER