30
Participants
Start Date
November 1, 2024
Primary Completion Date
June 1, 2028
Study Completion Date
June 1, 2029
Proton Beam Therapy
All patients to be offered neoadjuvant proton beam therapy to a dose of 45 Gray (Gy) in 15 fractions over 3 weeks, with a tumour boost to 67.5 Gray (Gy)
Concurrent oral capecitabine chemotherapy
All patients to be offered concurrent oral capecitabine 625mg/m2 twice daily on radiation days
Cisplatin & Gemcitabine intravenous chemotherapy
Following chemoradiotherapy (PBT + capecitabine), and whilst on the liver transplant waiting list, patients will be offered up to 6 cycles of standard chemotherapy with cisplatin and gemcitabine.
Orthotropic Liver Transplant
If still eligible after neoadjuvant treatment (PBT + capecitabine), patients will be added to the liver transplant waiting list.
University College London Hospitals
OTHER
University College, London
OTHER
Royal Free Hospital NHS Foundation Trust
OTHER
The Christie NHS Foundation Trust
OTHER