A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults

PHASE2CompletedINTERVENTIONAL
Enrollment

840

Participants

Timeline

Start Date

May 23, 2024

Primary Completion Date

November 21, 2024

Study Completion Date

June 4, 2025

Conditions
Influenza, Human
Interventions
BIOLOGICAL

Flu Seasonal mRNA Formulation 1

1 dose of Flu mRNA Formulation 1 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 2

1 dose of Flu mRNA Formulation 2 is administered intramuscularly in the non-dominant upper deltoid to YA at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 3

1 dose of Flu mRNA Formulation 3 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 4

1 dose of Flu mRNA Formulation 4 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 5

1 dose of Flu mRNA Formulation 5 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 6

1 dose of Flu mRNA Formulation 6 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 7

1 dose of Flu mRNA Formulation 7 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 8

1 dose of Flu mRNA Formulation 8 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

COMBINATION_PRODUCT

Active Comparator 1

1 dose of active comparator 1 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

COMBINATION_PRODUCT

Active Comparator 2

1 dose of active comparator 2 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 9

1 dose of Flu mRNA Formulation 9 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

BIOLOGICAL

Flu Seasonal mRNA Formulation 10

1 dose of Flu mRNA Formulation 10 is administered intramuscularly in the non-dominant upper deltoid to OA participants at Day 1.

COMBINATION_PRODUCT

Active Comparator 3

1 dose of active comparator 3 is administered intramuscularly in the non-dominant upper deltoid to YA participants at Day 1.

COMBINATION_PRODUCT

Active Comparator 4

1 dose of active comparator 4 is administered intramuscularly in the non-dominant upper deltoid to OA at Day1.

Trial Locations (18)

14609

GSK Investigational Site, Rochester

23502

GSK Investigational Site, Norfolk

23606

GSK Investigational Site, Newport News

27408

GSK Investigational Site, Greensboro

33012

GSK Investigational Site, Hialeah

33147

GSK Investigational Site, Miami

33186

GSK Investigational Site, Miami

37909

GSK Investigational Site, Knoxville

40509

GSK Investigational Site, Lexington

46383

GSK Investigational Site, Valparaiso

60640

GSK Investigational Site, Chicago

66219

GSK Investigational Site, Lenexa

67042

GSK Investigational Site, El Dorado

67114

GSK Investigational Site, Newton

67207

GSK Investigational Site, Wichita

76135

GSK Investigational Site, Fort Worth

77375

GSK Investigational Site, Tomball

78705

GSK Investigational Site, Austin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY