This is a Phase II, Open-label, Multicentre Study of Zanubrutinib-containing Regimens in Patients With Newly Diagnosed Mantle Cell Lymphoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

May 20, 2024

Primary Completion Date

December 30, 2027

Study Completion Date

December 30, 2029

Conditions
Lymphoma, Mantle-CellLymphoma, Non-Hodgkin
Interventions
DRUG

Zanubrutinib,Obinutuzumab

"Zanubrutinib, 160mg PO BID. C1D17 continuously for 1 year or until progressive disease; Obinutuzumab :Obinutuzumab will be administered 1,000 mg intravenously on days 1, 8, and 15 of cycle 1, then 1,000 mg on day 1 of cycles 2 to 6, then 1,000 mg every 8 weeks,up to 20 doses. 1 cycle = 28 days.~Maintenance: Zanubrutinib, 160mg PO BID"

DRUG

Zanubrutinib and R-BAC

"Induction: Zanubrutinib and R-BAC 6 cycles~Consolidation: ASCT(If eligible for transplantation),Otherwise, the patient was directly entered into maintenance treatment~Maintenance: Zanubrutinib continued until progression"

All Listed Sponsors
lead

Henan Cancer Hospital

OTHER_GOV