Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization

PHASE4CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

July 1, 2024

Primary Completion Date

January 3, 2025

Study Completion Date

January 7, 2025

Conditions
Molar Incisor Hypomineralization
Interventions
DRUG

Fluoride Varnishes

the investigators will utilize a fluoride varnish with a concentration of 22,600 ppm F. The application will be facilitated using a microbrush, ensuring thorough coverage over the entire length of the lesion for a duration of 30 seconds. Following application, the varnish will be finished with water to create a film on the tooth surface. After completing the interventions, patients will receive instructions to refrain from consuming hard foods and to postpone tooth brushing for at least four hours, adhering to the manufacturer's recommendations.

DRUG

Varnishes placebo

the investigators will apply a placebo varnish without the active ingredient (fluoride), ensuring that it is packaged identically to the fluoride varnish and has the same taste and texture, thus maintaining consistency in application. The varnish will be applied using a microbrush, spreading it evenly over the entire length of the lesion for a duration of 30 seconds. Following the interventions, patients will receive instructions to avoid consuming hard foods and to delay tooth brushing for at least four hours after applying the varnish.

RADIATION

Low-Intensity Laser 1J

The tooth will undergo low-intensity laser irradiation in continuous mode, employing a wavelength of 808 nm, a power output of 100 mW, a dose of 1 Joule, and a fluence of 35 J/cm\^2. The laser will be positioned perpendicular to the tooth surface, targeting the cervical third of the buccal surface (both mesial and distal aspects), as well as the center of the lesion.

RADIATION

Low-Intensity Laser 2J

The tooth will undergo low-intensity laser irradiation in continuous mode, employing a wavelength of 808 nm, a power output of 100 mW, a dose of 2 Joules, and a fluence of 35 J/cm\^2. The laser will be positioned perpendicular to the tooth surface, targeting the cervical third of the buccal surface (both mesial and distal aspects), as well as the center of the lesion.

Trial Locations (1)

14040904

Lucas Masaru Marubayashi, Ribeirão Preto

All Listed Sponsors
lead

University of Sao Paulo

OTHER

NCT06426108 - Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization | Biotech Hunter | Biotech Hunter