Nab-Paclitaxel Plus Cisplatin With Concurrent Radiotherapy for Patients With Locally Advanced Cervical Cancer: A Multicentre, Single-arm, Phase II Trial.

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

June 30, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

October 31, 2028

Conditions
Cervical Cancer
Interventions
RADIATION

radiotherapy

Image guidance volume modulated arc therapy included 50.4 Gy in 28 fractions to the pelvis and 59.4 Gy simultaneous boost in 28 fractions to involved pelvic and para-aortic lymph nodes, and subsequent high-dose-rate intracavitary brachytherapy at a total dose of 30.0-36.0 Gy in 5-6 fractions, twice a week.

DRUG

Nab paclitaxel

Concurrent chemotherapy regimen included weekly cisplatin (40 mg/m\^2) and weekly nab-paclitaxel at escalating doses (33 mg/m\^2 per week).

DRUG

Cisplatin

Concurrent chemotherapy regimen included weekly cisplatin (40 mg/m\^2) and weekly nab-paclitaxel at escalating doses (33 mg/m\^2 per week).

All Listed Sponsors
collaborator

Jilin Provincial Tumor Hospital

OTHER

collaborator

Affiliated Hospital of Hebei University

OTHER

collaborator

Hebei Medical University Fourth Hospital

OTHER

lead

Peking University Third Hospital

OTHER

NCT06426056 - Nab-Paclitaxel Plus Cisplatin With Concurrent Radiotherapy for Patients With Locally Advanced Cervical Cancer: A Multicentre, Single-arm, Phase II Trial. | Biotech Hunter | Biotech Hunter