Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)

PHASE4RecruitingINTERVENTIONAL

Enrollment

150

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

July 1, 2026

Study Completion Date

December 31, 2026

Conditions

Knee Osteoarthritis

Interventions

DRUG

Duloxetine

60mg duloxetine given 2 weeks prior to total knee arthroplasty and continued for 6 weeks after surgery.

DRUG

Placebo

Placebo given 2 weeks prior to total knee arthroplasty and continued for 6 weeks after surgery.

Trial Locations (1)

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

All Listed Sponsors

lead

Sunnybrook Health Sciences Centre

OTHER