Effect of Sodium-glucose Cotransporter-2 Inhibitors (SGLT-2i) on Proteinuria in Nephrotic Children Older Than 10 Years

PHASE4RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

January 31, 2025

Study Completion Date

August 31, 2025

Conditions
Nephrotic Syndrome in Children
Interventions
DRUG

ACEI, SGLT-2i

"Group 1 (ACEI group) will receive a single dose of oral ACE inhibitors tablets per day (0.2-0.6mg) /kg/ day)~❖ Group 2 (combined ACEI and SGLT-2inhibitrs group) patients on a single dose of oral ACE inhibitors tablets per day (0.2-0.6mg /kg/ day) presenting with persistent nephrotic range proteinuria will add a single dose of oral SGLT-2 inhibitors tablets 5mg per day (weight≤30kg) or 10mg per day (weight \>30kg)"

Trial Locations (1)

35516

RECRUITING

Mansoura University Children's Hospital, Al Mansurah

All Listed Sponsors
lead

Mansoura University

OTHER