250
Participants
Start Date
February 13, 2024
Primary Completion Date
December 1, 2028
Study Completion Date
December 1, 2029
Buprenorphine or Methadone Treatment
Pregnant mothers must be taking Buprenorphine or Methadone
Fetal and Placental MRI
"Two MRIs :~* Second Trimester~* Third Trimester"
Child Developmental Assessment
At 1 year of life child will receive a developmental assessment
Questionnaires
Participants will answer questionnaires on their medical history, pregnancy, substance use, and after birth: their child's development
Blood and Placental Samples
"At each MRI visit a blood sample will be collected for substances, DNA, RNA, epigenetics, and placental biomarkers.~At delivery: A sample of placenta will be collected for RNA, DNA, and epigenetic analysis."
University of Pittsburg, Pittsburgh
Riley Hospital for Children, Indianapolis
National Institute on Drug Abuse (NIDA)
NIH
Indiana University
OTHER