Camrelizumab Plus Fluzoparib for TP-53 Mutated Endometrial Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

117

Participants

Timeline

Start Date

May 10, 2024

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2027

Conditions
Endometrial CarcinomaTP53 MutationRecurrent or Metastatic
Interventions
DRUG

Fluzoparib

During the maintenance phase of treatment. Oral administration of Fluzoparib capsules at a dose of 150mg(N=78 participants), once in the morning and once in the evening until disease progression, intolerable toxicity, death, or up to a maximum of 2 years.

DRUG

Camrelizumab

During the maintenance phase of treatment. Camrelizumab, 200 mg administered intravenously every 3 weeks until disease progression, intolerable toxicity, death, or up to 2 years.

DRUG

paclitaxel (albumin bound)

Paclitaxel (albumin-bound) for injection, 260 mg/m\^2 administered intravenously in 3-week cycles for 6 cycles.

DRUG

Carboplatin injection

AUC=5 Intravenous dosing is administered every 3 weeks for a total of 6 treatment cycles. Specific dosing cycles may be determined by the investigator

DRUG

Carboplatin

AUC=5 Intravenous dosing is administered every 3 weeks for a total of 6 treatment cycles. Specific dosing cycles may be determined by the investigator

RADIATION

External irradiation

Non-essential, decision to combine is made by the principal investigator based on the patient's condition.

Trial Locations (1)

100021

RECRUITING

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER