Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia

We will measure muscle activity using surface electromyography and tremor using inertial measurement units while subjects perform rest, posturing and kinetic tasks.

We will obtain B-mode images and videos of upper extremity muscles of the most affected upper extremity.

Subjects will undergo (f)MRI scanning involving concurrent electromyography, accelerometry and functional magnetic resonance imaging.

We will assess tremor and dystonia severity using clinical scales.

We will collect patient-reported outcomes.

Three consequetive botulinum toxin injections of the upper extremities