MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

"Participating patients will undergo the following evaluations at baseline and after six months of treatment with MitoQ or placebo:~Assessment of walking impairment: Evaluation of treadmill maximum walking distances, six-minute walking distance, and daily physical activity (average steps taken daily)"

Assessment of quality of life: Survey of Quality of life with the Walking Impairment Questionnaire and Short Form 36

Assessment of leg hemodynamics: Evaluation of post-occlusive ankle pressure and ankle/brachial index

Evaluation of calf muscle heme oxygen saturation

Evaluation of serum concentrations of MitoQ

Needle biopsy of the calf muscle