Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy

NANot yet recruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Postoperative PainAnalgesiaSupratentorial Brain Tumor
Interventions
DRUG

Dexmedetomidine

The 200ug dexmedetomidine will be diluted into a 50ml syringe and administered with 0.4ug/kg/h intraoperatively and 0.05 μg/kg/h for 48 hours after surgery.

DRUG

Normal saline

In the placebo group, the 0.9% saline is administered with the same volume at the same speed as the dexmedetomidine group

OTHER

Local analgesic techniques

The 10ml 1% ropivacaine will be diluted into a 20ml syringe . As for scalp nerve block, each nerve will be blocked separately with 1-2 mL 0.5% ropivacaine.

OTHER

no Local analgesic techniques

No Local analgesic techniques will be given.

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER

NCT06406829 - Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy | Biotech Hunter | Biotech Hunter