NCT06406777View on ClinicalTrials.gov

Chronic Lung Allograft Dysfunction MRI Study

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

March 20, 2025

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2028

Conditions
Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
Interventions
DIAGNOSTIC_TEST

Spirometry

Spirometry measures lung function, specifically the amount and/or speed of air that can be inhaled and exhaled.

DIAGNOSTIC_TEST

Contrast Lung Computed Tomography (CT) Scan

CT scan of the lungs using contrast

DIAGNOSTIC_TEST

Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan

MRI will be taken while subject is lying on their back breathing 100% oxygen.

DRUG

129Xe MRI scans

MRI will be taken while subject is lying on their back breathing room oxygen and taking a breath of 129Xe and holding it for a few seconds.

Trial Locations (1)

52242

RECRUITING

University of Iowa, Iowa City

All Listed Sponsors
lead

Sean Fain

OTHER