A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

April 25, 2024

Primary Completion Date

May 31, 2026

Study Completion Date

April 30, 2027

Conditions
Non-small Cell Lung CancerColorectal CancerPancreatic CancerSolid Tumor
Interventions
DRUG

QLC1101

QLC1101 is an innovative small molecule inhibitor targeting KRAS G12D with independent intellectual property rights developed by Qilu Pharmaceutical Co., Ltd.QLC1101 can prevent GTP/GDP nucleotide exchange and/or the formation of KRAS G12D/GTP/RAF1 complex and inhibit mutant KRAS-dependent signal transduction by specifically binding to the KRAS G12D target, thereby inhibiting the generation of KRAS G12D mutant tumors.

Trial Locations (5)

150081

NOT_YET_RECRUITING

Harbin Medical university cancer hospital, Harbin

200000

RECRUITING

Shanghai east hospital, Shanghai

330029

NOT_YET_RECRUITING

Jiangxi Cancer Hospital, Nanchang

510699

NOT_YET_RECRUITING

The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou

650118

NOT_YET_RECRUITING

Yunnan Cancer Hospital, Kunming

All Listed Sponsors
lead

Qilu Pharmaceutical Co., Ltd.

INDUSTRY

NCT06403735 - A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter