FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC

PHASE2RecruitingINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

June 1, 2024

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2026

Conditions
Non-small Cell Lung Cancer
Interventions
COMBINATION_PRODUCT

Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy

Participants will receive FMT combined with tislelizumab + pemetrexed + platinum-based treatment (lung adenocarcinoma) / albumin-bound paclitaxel + platinum-based treatment (lung squamous cell carcinoma) for 4-6 cycles. If there is no progression of the disease after 4-6 cycles of the first-line treatment, then patients will enter the maintenance treatment stage. Patients will receive tislelizumab maintenance treatment (lung squamous cell carcinoma), or tislelizumab + pemetrexed maintenance treatment (lung adenocarcinoma).

Trial Locations (1)

Unknown

RECRUITING

Changzhou No.2 Poeple's Hospital, Changzhou

All Listed Sponsors
lead

Changzhou No.2 People's Hospital

OTHER