A Phase 2b Study of Zagociguat in Patients With MELAS

PHASE2RecruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

September 10, 2024

Primary Completion Date

June 20, 2026

Study Completion Date

June 20, 2026

Conditions
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Interventions
DRUG

zagociguat 15mg

Once-daily oral tablets

DRUG

zagociguat 30mg

Once-daily oral tablets

DRUG

Placebo

Once-daily oral tablets

Trial Locations (25)

3052

RECRUITING

Royal Melbourne Hospital, Melbourne

10027

RECRUITING

Columbia University Irving Medical Center, New York

10029

RECRUITING

Mount Sinai - Ichan School of Medicine, New York

15224

ACTIVE_NOT_RECRUITING

UPMC Children's Hospital of Pittsburgh, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

WITHDRAWN

Children's National, Washington D.C.

20133

RECRUITING

Neurologic Institute Carlo Besta of Milan, Milan

21287

RECRUITING

Johns Hopkins University School of Medicine, Baltimore

30329

RECRUITING

Rare Disease Research, Atlanta

44308

RECRUITING

Akron Children's Hospital, Akron

53127

RECRUITING

University Hospital Bonn, Bonn

55905

RECRUITING

Mayo Clinic Rochester, Rochester

56100

ACTIVE_NOT_RECRUITING

University of Pisa Neurological Clinic, Pisa

77030

RECRUITING

Baylor College of Medicine, Houston

RECRUITING

University of Texas Medical School at Houston, Houston

80045

RECRUITING

Children's Hospital of Colorado, Aurora

80336

RECRUITING

Ludwig-Maximilians-University of Munich, Munich

92037

RECRUITING

UC San Diego - Altman Clinical and Translational Research Institute, La Jolla

02114

RECRUITING

Massachusetts General Hospital, Boston

NSW 2031

RECRUITING

Neuroscience Research Australia, Sydney

R3A1R9

RECRUITING

Shared Health/University of Manitoba, Winnipeg

L8N 3Z5

RECRUITING

McMaster University Medical Center, Hamilton

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

WC1N 3BG

RECRUITING

UCL Queen Square Institute of Neurology, London

NE14LP

RECRUITING

Newcastle University, Newcastle upon Tyne

Sponsors
All Listed Sponsors
lead

Tisento Therapeutics

INDUSTRY