Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir

RecruitingOBSERVATIONAL
Enrollment

64

Participants

Timeline

Start Date

October 30, 2023

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2027

Conditions
Leptomeningeal MetastasisLung Cancer
Interventions
DRUG

Pemetrexed injection

Group 1(20mg):induction stage is 20 mg per 24 hours for 72 hours, every 2 weeks; consolidation stage is 20mg per 24 hours for 72 hours, every 3 weeks.

DRUG

Pemetrexed

Group 2(30mg):induction stage is 30 mg D1,every week.Consolidation stage is 30 mg D1,every 3 weeks.

Trial Locations (1)

410008

RECRUITING

Xiangya Hospital Central South University, Changsha

All Listed Sponsors
collaborator

First People's Hospital of Chenzhou

OTHER

collaborator

Xiangtan Central Hospital

OTHER

lead

Xiangya Hospital of Central South University

OTHER