1,740
Participants
Start Date
June 6, 2024
Primary Completion Date
April 30, 2027
Study Completion Date
May 31, 2027
Normal saline
20 ml of normal saline is infused intravenously at 80 ml/h after anesthesia induction but before surgery.
Dexmedetomidine
Dexmedetomidine 0.5 μg/kg, diluted with normal salinet o 20 ml, is infused intravenously at 60 ml/h after anesthesia induction but before surgery.
Esketamine
Esketamine 0.25 mg/kg, diluted with normal saline to 20 ml, is infused intravenously at 80 ml/h after anesthesia induction but before surgery.
Combined dexmedetomidine-esketamine
Dexmedetomidine 0.5 μg/kg and esketamine 0.25 mg/kg, diluted with normal saline to 20 ml, is infused intravenously at 80 ml/h after anesthesia induction but before surgery.
RECRUITING
Peking University First Hospital, Beijing
RECRUITING
Peking University Shenzhen Hospital, Shenzhen
Peking University Shenzhen Hospital
OTHER
Peking University First Hospital
OTHER