Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients with Severe Acute Brain Injury

NARecruitingINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

May 8, 2024

Primary Completion Date

October 8, 2025

Study Completion Date

December 31, 2026

Conditions
Acute Brain Injury
Interventions
OTHER

Hyperglycaemic clamp

"Following an overnight fast, the investigators will perform simultaneous samples from the arterial line, the venous line, and microdialysis and consider these samples as baseline values.~If the patient's blood glucose level is at 8-10 mmol/L at baseline, the investigators will not proceed with the intervention and instead evaluate if the intervention can take place the following day.~After baseline values are measured, intravenous glucose 20% (200g/1,000 ml) is infused to raise the glucose levels in both plasma and extravascular glucose compartments with approximately 3 mmol/L."

Trial Locations (2)

2100

RECRUITING

Department of Neuroanaesthesiology, Rigshospitalet, Copenhagen

RECRUITING

Rigshospitalet, Copenhagen

All Listed Sponsors
lead

Rigshospitalet, Denmark

OTHER